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Andalusian researchers

STRESS THE ROLE OF

IMMUNE SYSTEM IN

DEVELOPMENT OF DISEASE

NEURODEGENERATIVE

Traditionally, research on neurodegenerative diseases like Alzheimer's or Parkinson has focused on the study of mechanisms of neuronal degeneration of the central nervous system, without considering the importance of the immune system as a trigger or chronic. Investigations by a group of Andalusian Center Molecular Biology and Regenerative Medicine (CABIMER) , directed by David Pozo, go one step further deepen the study of mechanisms that disrupt the immune system, many common diseases such as Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Alzheimer's or Parkinson

Laboratory and Advanced Therapies in Immune Neuroprotection of Centro Andaluz Biology Molecular and Regenerative Medicine (CABIMER) , directed by David Well, consider that the immune system plays an important role as a trigger or chronic, neurodegenerative disease. It is focus on the study of the mechanisms that alter, many common diseases such as Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Alzheimer's and Parkinson's.

"Our strategy is to try to understand the mechanisms of deregulation of the immune system to modulate, if possible, through the use of endogenous molecules found in our body, as certain neuropeptides. They are small proteins produced by both nerve cells and the immune system, as part of the molecular framework by which these systems talk to each other. In particular we study the axis formed by the neuropeptides VIP (vasoactive intestinal peptide) capable of modifying the inflammatory response and immune tolerance, and the molecule ADNP (Activity Dependent Neuroprotective Protein ), neuroprotective effect, "says researcher .


Dual function
These therapeutic approaches have implied a dual role: immunomodulatory because it modifies the immune response to halt the neurodegenerative process, and neuroprotective. His works are aimed at the intervention of the processes of balancing the immune system, either through direct use of neuropeptides, or by cell therapy. In the latter, the experimental framework, would infuse the patient immune cells-regulatory T specific antigen, a substance that triggers the formation of antibodies and can cause an autoimmune response.

'own cells are patient could then be used ex vivo manipulation in the laboratory. This act by turning off the immune response specifically, promoting tolerance to a particular antigen, in this case, the trigger of the neurodegenerative process, "says David Pozo, which states:" Although the results have been obtained from tests in animal models, other research groups have worked infusing T-regulatory cells in patients with MS. "

Through these trials, "we are beginning to understand when and where to manipulate an immune response inflammatory central nervous system, encouraging even a positive response to treat neurodegeneration, "says David Pozo.

result of this work are the publications in international refereed journals as Nanomedicine, EMBO Journal, Journal of Immunology or PLOSOne , next to the record of 5 patents, three of them involving the universities of Seville and Pablo de Olavide the Superior Council Scientific Research (CSIC) and Reina Mercedes Foundation for Health Research, and the two most recent in 2011: " Nanoliposomas functionalized with peptides, Sevilla University and Service Andalusian Health.